The Bladder Outlet-Cancer Score (BOCS) As a prognostic tool for therapy-response in bladder cancer patients

Evaluating the Expression of Oct4 as a Prognostic Tumor Marker in Bladder Cancer

Objective(s)The key transcriptional regulator Oct4 is one of the self-renewal and differentiation-related factors in cancer stem cells, where it maintains "stemness" state. Cancer stem cells have been identified in a variety of solid malignancies. They are a small population of tumor cells with stem cell characteristics, which are a likely cause of relapse in cancer patients. Due to high incide...

MicroRNAs as biomarkers associated with bladder cancer

Bladder cancer is the fifth most common cancer with significant morbidity and mortality. Recently, numerous studies demonstrated that microRNAs are emerging as diagnostic biomarkers for bladder cancer. Specific miRNA profiles have been identified for several samples from patients with bladder cancer. MicroRNAs are noncoding RNA molecules of approximately 23 nucleotides that play important roles...

Prognostic Impact for Bladder Cancer Patients

A review of biomarkers in the diagnosis of bladder cancer

Bladder cancer is among the ten most common cancers and the ten main causes of cancer-related deaths in the world. Currently, bladder tumors are diagnosed and followed up using a combination of cystoscopy and cytology. In addition, bladder cancer often recurs and can progress if not closely monitored after initial treatment. Constant monitoring of the patient with cystoscopy, which is an invasi...

Role of MicroRNAs in BCG Therapy by the Induction of Neutrophil Extracellular Traps in Bladder Cancer

The treatment of bladder cancer is usually performed by Bacillus Calmette-Guerin (BCG) instillation. BCG therapy is a common therapeutic method with fewer side effects compared with chemotherapy, radiotherapy, etc. BCG can also inhibit the progression and recurrence of bladder cancer by inducing apoptosis pathways, arrest cell cycle, autophagy, and neutrophil extracellular traps (NETs) formatio...